The best Side of LDN-27219 side effects
A single particularly exciting compound is LDN-27219. When most tTG inhibitors are intended to bind to the protein crosslinking active site, LDN-27219 instead binds into the nucleotide binding pocket with the enzyme while it can be in its closed-state conformation, and stabilizes that conformation to prevent crosslinking activity.78 Schneider et al